রবিবার, ৩০ জুন, ২০১৩

White Makes First Cut For World University Games

Incoming Iowa junior Aaron White was named one of 16 finalists for the U.S.A. World Men?s World University Games roster.

Tryouts continue for the 12-member squad through June 30. The team leaves for Kazan, Russia on July 1 with competition held July 7-16. Iowa guard Devyn Marble, who also tried out for the team, was not named a finalist.

White, a 6-foot-8 forward, was named third-team all-Big Ten and led Iowa in rebounding (6.2), the first Hawkeye to lead the team in rebounding as a freshman and sophomore since Michael Payne in 1981-82. He ranked second on the team in scoring (12.8) and steals (41). White made (193) and attempted (258) the most free throws of any sophomore in Iowahistory. In two seasons, White has scored 877 career points.

Four Big Ten players are listed as finalists: White, Adreian Payne (Michigan State), Yogi Ferrell (Indiana) and Will Sheehey (Indiana). Marble, Andre Hollins (Minnesota) and A.J. Hammons (Purdue) were not selected as finalists.

Other finalists include: Spencer Dinwiddie (Colorado); Davante Gardner (Marquette); Treveon Graham (Virginia Commonwealth); Jerian Grant(Notre Dame); Luke Hancock (Louisville); Tyler Haws (BYU); Rodney Hood (Duke); Cory Jefferson (Baylor); Sean Kilpatrick (Cincinnati); Alex Kirk (New Mexico); Doug McDermott (Creighton); Chasson Randle (Stanford).

Source: http://www.kcrg.com/sports/hawkeyes/White-Makes-First-Cut-For-World-University-Games-213258201.html

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Biomarker predicts risk of breast cancer recurrence after tamoxifen treatment

June 29, 2013 ? A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen-receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment. In their report being published online in the Journal of the National Cancer Institute, Massachusetts General Hospital (MGH) Cancer Center investigators describe finding that the HOXB13/IL17BR ratio can indicate which women are at risk for cancer recurrence after tamoxifen and which are most likely to benefit from continuing treatment with the aromatase inhibitor letrozole (Femara).

"Most patients with early-stage, ER-positive breast cancer remain cancer-free after five years of tamoxifen treatment, but they remain at risk of recurrence for 15 years or longer after their initial treatment," says Dennis Sgroi, MD, of the MGH Cancer Center and Department of Pathology, lead and corresponding author of the report. "Our biomarker identifies the subgroup of patients who continue to be at risk of recurrence after tamoxifen treatment and who will benefit from extended therapy with letrozole, which should allow many women to avoid unnecessary extended treatment."

Previous research by Sgroi's team, in collaboration with investigators from bioTheranostics Inc., discovered that the ratio between levels of expression of two genes -- HOXB13 and IL17BR -- in tumor tissue predicted the risk of recurrence of ER-positive, lymph-node-negative breast cancer, whether or not the patient was treated with tamoxifen. The current study of patients from MA.17, the highly successful clinical trial of letrozole, was designed to evaluate the usefulness of the HOXB13/IL17BR ratio for both prognosis -- predicting which tamoxifen-treated remained patients at risk of recurrence -- and for identifying who could benefit from continued treatment with letrozole.

To answer those questions the investigators analyzed primary tumor samples and patient data from the placebo-controlled MA.17 trial, which confirmed the ability of extended letrozole therapy to improve survival after the completion of tamoxifen treatment. Tissue samples were available from 83 patients whose tumors recurred during the study period -- 31 who had received letrozole and 52 in the placebo group -- and 166 patients with no recurrence, 91 of whom had received letrozole, with 75 getting the placebo. Analysis of the tumor samples revealed that a high HOXB13/IL17BR ratio -- meaning the expression level of HOXB13 is greater than that of IL17BR -- predicts an increased risk for tumor recurrence after tamoxifen therapy, but that elevated risk drops significantly if a patient receives letrozole

Paul E. Goss, MD, PhD, director of the Breast Cancer Research Program at the MGH Cancer Center and a co-author of the report, explains, "This discovery means that about 60 percent of women with the most common kind of breast cancer can be spared unnecessary treatment with the concommitant side effects and costs. But more importantly, the 40 percent of patients who are at risk of recurrence can now be identified as needing continued therapy with letrozole, and many will be spared death from breast cancer." He and Sgroi note that their findings need to be validated by additional studies before they can be put into clinical practice.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/kFmW4R0U9Fo/130629164733.htm

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শনিবার, ২৯ জুন, ২০১৩

NASA Space Shuttle Runway Gets New Life as Commercial Spaceport

CAPE CANAVERAL, Fla. ? The famous?seaside?space shuttle runway here at NASA's Kennedy Space Center may have a second life soon as a launch and landing spot for a whole new type of space mission: tourist flights.

The 15,000-foot-long (4,600 meters)?Shuttle Landing Facility (SLF) has been unused for spaceflights since the 30-year space shuttle program retired in 2011. But now NASA is handing over operation of the facility to Space Florida, the aerospace economic development agency for the state of Florida, to put the runway to new uses.

"Space Florida will take over operation of SLF as a combined airport and spaceport," NASA administrator Charles Bolden said here at a press conference today (June 28). "This will continue to expand Kennedy's viability as a multiuser spaceport. We look forward to working with Space Florida over the coming months." [Photos: NASA's Last Shuttle Landing in History]

Space Florida hopes to recruit commercial space companies to perform launches and landings from the Shuttle Landing Facility. The organization has reached out to suborbital launch company XCOR Aerospace, as well as orbital spaceship builders Sierra Nevada Space Systems, Boeing and Space Exploration Technologies Corp. (SpaceX), and has high hopes many of these companies will establish operations at Kennedy Space Center.

"It's our job to make it a commercial entity ?we're excited for the challenge," Jim Kuzma, senior vice president and chief operating officer of Space Florida, told SPACE.com.

NASA itself may prove to be a customer of the facility when it starts launching its new heavy-lift rocket, the Space Launch System, and Orion spacecraft, in coming years. Under the new arrangement, NASA is no longer shouldering the everyday cost of running the Shuttle Landing Facility ? Florida is ? so if NASA uses the facility it will have to pay for it like any other customer.

"It's exciting for Florida," Kuzma said. "We think the work force is here, the understanding of the needs of the space industry is here."

Andrew Nelson, chief operating officer of XCOR Aerospace, which hopes to begin launching tourists to the edge of space on its Lynx vehicle soon, agreed.

"The workforce is incredible here," he said. "There's just something in the DNA here."

XCOR said it was attracted to the idea of launching flights out of Kennedy Space Center in part because the Space Coast lures so many tourists ? it's about an hour's drive from the tourist Mecca of Orlando.

"There are 30 million tourist visitors a year here," Nelson told SPACE.com. "A few are going to want to fly to space."

Follow Clara Moskowitz on Twitter?and Google+. Follow us?@Spacedotcom, Facebook?and Google+. Original article on?SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/nasa-space-shuttle-runway-gets-life-commercial-spaceport-115756289.html

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Paula Deen, Proposition 8, and the sometimes-nuance of bigotry (Americablog)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/315912495?client_source=feed&format=rss

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How Gazprom's $1 trillion dream has fallen apart

By Vladimir Soldatkin

MOSCOW (Reuters) - Zoya Danilina, who owns some 700 shares in Gazprom , says investors don't have to look far to understand that Russia's most powerful company has lost its way.

Danilina remembers when her shares were worth over 300 roubles each. Now they fetch about 100 roubles.

"There have been much better days, when tables were served with black and red caviar," she said on the sidelines of Gazprom's annual general meeting in Moscow on Friday, looking at a plate of boiled buckwheat, a popular staple food in Russia.

In the caviar era, Gazprom head Alexei Miller, a close ally of President Vladimir Putin, was overseeing a company with the world's third-largest market value at $360 billion. In 2007, he promised to boost it to $1 trillion.

Fast forward several years and Gazprom, still the world's largest gas producer and holder of 15 percent of global gas reserves, is worth $77 billion and could fall further as it faces a series of setbacks.

The biggest blow came from a shale gas revolution that has unlocked vast reserves in the United States.

U.S. prices have crashed, closing America as a prospective market for Gazprom, diverting cheaper liquefied natural gas (LNG) cargoes not needed in the United States to Europe, undermining Gazprom's position in its core market.

Europe, tied to Gazprom by a Soviet-built pipeline network, has balked at its contracts that tie gas prices to more expensive oil.

Last year, Miller was forced to offer billions of dollars in what Gazprom described as "rebates" to European buyers.

On Thursday, Germany's RWE said it won an arbitration case against Gazprom, which further loosened the price link to oil and raised the prospect of more price concessions.

Gazprom expects its 2013 earnings to fall by 10 percent, marking a second yearly decline.

The stock market now values Gazprom - the world's third-biggest company by earnings behind ExxonMobil and Apple - at only two times its 2012 earnings of $38 billion. That makes it the cheapest large-cap stock on an already cheap Russian market.

LNG, HOME PRICE SETBACKS

Investors could possibly forgive those setbacks if they were confident Gazprom could expand in the fast growing global LNG markets, while charging rising prices at home.

"Our goal is to control around 15 percent of the global market for liquefied natural gas," Miller, 51, told the annual general meeting on Friday.

But such hopes were dealt heavy blows over the past month.

Putin signaled last week the gradual end of Gazprom's monopoly on exports of LNG and opened the way for rivals Novatek and Rosneft to compete for huge new Asian markets.

"We offer to lower restrictions gradually on liquefied natural gas exports," Putin said in a speech at an economic forum in St Petersburg, both his and Miller's hometown.

Putin also said that monopolies would be able to raise prices only in line with inflation, reducing hopes for much higher returns on the domestic market.

Gazprom's domestic industrial customers pay $114 per 1,000 cubic meters - little more than half of the $201 it receives for exports after being adjusted for transportation and duties.

"Investors are structurally underweight Gazprom as they do not believe in significant change at the company," said Kingsmill Bond, chief strategist at Sberbank Investment Research in Moscow.

POLITICAL TOOL

Under Miller, hired by Putin in 2001, Gazprom often served as a Kremlin political tool, as described by EU officials.

"The Kremlin has decided that Gazprom is part of Russia's national security and geopolitics - not a commercial company," said Chris Weafer, founder of Macro Advisory, a Russia-focused consultancy.

"We are going back to Soviet days, when Gazprom was a government ministry. The market is valuing it like a ministry."

Using Gazprom as a weapon has proved to be a double-edged sword, poisoning relations with Ukraine, the transit route for most of Gazprom's Europe-bound gas, after several pricing disputes, which cut gas flows to Europe during several winters.

Gazprom is now investing billions of dollars in new export routes to circumvent is ex-Soviet neighbor - Nord Stream to Germany and the still-to-be built South Stream to Italy.

Investors fear those projects may never pay out.

Finally, Gazprom has failed to sign a supply deal with China, the world's largest energy market, despite first signing a memorandum of understanding as long ago as 2006.

Should the deal be signed before the end of the year, it may still not be enough to revive the appetite of investors, who have long criticized Gazprom's for overspending.

"The mega-projects will guarantee rapid growth in costs, while future revenues are absolutely uncertain," said Mikhail Korchemkin of consultancy East European Gas Analysis.

(Corrects to one trillion dollars from one billion in fourth par)

(Additional reporting by Denis Pinchuk and Douglas Busvine; Editing by Dmitry Zhdannikov and Jane Baird)

Source: http://news.yahoo.com/gazproms-1-trillion-dream-fallen-apart-181422124.html

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Former Tesco chairman says turnaround could take three years

LONDON (Reuters) - A former chairman of Tesco , the world's No.3 retailer, said that restoring the store group's fortunes could take up to three years and appealed to investors to give Chief Executive Phil Clarke sufficient time.

Once one of the most consistent British companies in terms of earnings growth, Tesco, which trails France's Carrefour and U.S. group Wal-Mart by annual sales, has had a particularly testing year.

In April the firm posted its first profit fall in two decades, wrote down the value of its global operations by $3.5 billion and confirmed plans to exit its loss-making U.S. business Fresh & Easy.

"We're all very sad in this room to see the legacy that Terry Leahy (CEO from 1997 to 2011) left," Ian MacLaurin told shareholders on Friday at the firm's annual meeting.

"It is a very sad situation - your enormous writedowns, (and) the situation in America," said MacLaurin, who chaired Tesco from 1985 to 1997.

MacLaurin said Tesco's board and shareholders had to counter "an age of short-termism" by taking a long-term view and giving Clarke - who took over from Leahy in March 2011 - and his team time to fix things.

"This job is going to be probably two or three years," he said.

Tesco avoided a rebellion from investors over executive pay at the AGM.

Some 95.2 percent of shareholders who voted at the meeting backed the firm's executive pay report, even though advisory group Pensions Investment Research Consultants (Pirc) had called on investors to vote against it in protest at what it regarded as excessive payoffs to two departed executives.

Tesco paid Tim Mason, the former boss of Fresh & Easy, and Richard Brasher, ousted as the head of the UK business in March 2012, "liquidated damages" of 1.68 million pounds ($2.6 million) and 1.3 million pounds respectively in the 2012-13 year. ($1 = 0.6577 British pounds)

(Reporting by James Davey, Editing by Rosalba O'Brien)

Source: http://news.yahoo.com/former-tesco-chairman-says-turnaround-could-3-years-140716181.html

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Hospitals seek high-tech help for hand hygiene

RICHMOND HEIGHTS, Mo. (AP) ? Hospitals have fretted for years over how to make sure doctors, nurses and staff keep their hands clean, but with only limited success. Now, some are turning to technology ? beepers, buzzers, lights and tracking systems that remind workers to sanitize, and chart those who don't.

Health experts say poor hand cleanliness is a factor in hospital-borne infections that kill tens of thousands of Americans each year. The U.S. Centers for Disease Control and Prevention in Atlanta estimates that one of every 20 patients in U.S. hospitals gets a hospital-acquired infection each year.

"We've known for over 150 years that good hand hygiene prevents patients from getting infections," said Dr. John Jernigan, an epidemiologist for the CDC. "However, it's been a very chronic and difficult problem to get adherence levels up as high as we'd like them to be."

Hospitals have tried varying ways to promote better hygiene. Signs are posted in restrooms. Some even employ monitors who keep tabs and single out offenders.

Still, experts believe hospital workers wash up, at best, about 50 percent of the time. One St. Louis-area hospital believes it can approach 100 percent adherence.

Since last year, SSM St. Mary's Health Center in the St. Louis suburb of Richmond Heights, Mo., has been the test site for a system developed by Biovigil Inc., of Ann Arbor, Mich. A flashing light on a badge turns green when hands are clean, red if they're not. It also tracks each hand-cleaning opportunity ? the successes and the failures.

The failures have been few at the two units of St. Mary's where the system is being tested, the hospital said. One unit had 97 percent hand hygiene success, said Dr. Morey Gardner, the hospital's director of infection disease and prevention. The other had 99 percent success.

"The holy grail of infection prevention is in our grasp," Gardner said.

The Biovigil system is among many being tried at hospitals. A method developed by Arrowsight, based in Mt. Kisco, N.Y., uses video monitoring. It is being used in intensive care units at North Shore University Hospital in Manhasset, N.Y., and the University of California San Francisco Medical Center.

Akron, Ohio-based GOJO Industries, maker of Purell hand sanitizer, has developed an electronic compliance monitoring system using wireless technology to track when soap and hand sanitizer dispensers are used. The SmartLink system gives the hospital data on high- and low-compliance areas. The company said it has installed the system at several hospitals around the country, but didn't say how many.

HyGreen Inc.'s Hand Hygiene Reminder System was developed by two University of Florida doctors. The Gainesville, Fla., company now features two systems used in seven hospitals, including Veterans Administration hospitals in Chicago, Wilmington, Del., and Wilkes-Barre, Pa.

One is similar to Biovigil's green badge method. In HyGreen's, a wall-mounted hand wash sensor detects alcohol on the hands. The badge includes an active reminding system. Unclean hands create a warning buzz. If the buzz sounds three times, the worker is noted for noncompliance.

HyGreen spokeswoman Elena Fraser said that because some hospitals are moving away from alcohol-based sanitizers, HyGreen offers a second system. A touch of the sanitizer dispenser clears the worker to interact with a patient. If the worker shows up at the patient bed without hand-cleaning, the series of warning buzzes begins.

Fraser said hospital infections have dropped 66 percent at units of Miami Children's Hospital where the badge system has been implemented.

Nurses using the Biovigil system at St. Mary's near St. Louis wear a badge with changeable colored lights. A doorway sensor identifies when the nurse enters a patient's room, and the badge color changes to yellow.

The nurse washes his or her hands and places them close to the badge. A sensor in the badge detects chemical vapors from the alcohol-based solution. If hands are clean, the badge illuminates a bright green hand symbol.

If the nurse fails to sanitize, the badge stays yellow and chirps every 10 seconds for 40 seconds, then flashes red. Once the flashing red starts, the nurse has another 30 seconds to wash up, otherwise the badge turns solid red, denoting non-compliance. Either way, each instance is tracked by a computer. The hospital can track each individual's compliance.

Registered Nurse Theresa Gratton has helped lead the effort toward hand cleanliness at St. Mary's. She heard about the Biovigil system in early 2012 and convinced the hospital to give it a try.

Gratton said patients are aware of the risk of infection and frequently inquire about whether caregivers have washed their hands. She said the badge relieves their anxiety.

Bill Rogers, a 65-year-old retiree recuperating at St. Mary's from back surgery and a heart scare, agreed.

"The first thing I noticed up here was the badges," Rogers said. "It is comforting for me to know their hands are clean as soon as the badge beeps and it goes from yellow to green."

St. Mary's is expanding the Biovigil system later this year to other units of the hospital and to employees other than nurses, though details are still being worked out, Gardner said. Eventually, the system may be expanded to SSM's seven other St. Louis-area hospitals, he said.

Biovigil's chief client officer, Brent Nibarger, said customers won't buy the system but will pay a subscription fee of about $12 a month per badge.

The CDC's Jernigan said the high-tech systems can only help.

"For a health care worker, keeping their hands clean is the single most important thing they can do to protect their patients," Jernigan said.

Source: http://news.yahoo.com/hospitals-seek-high-tech-help-hand-hygiene-071012525.html

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Wall Street Fundamentals Releases New In-Depth Stock Reports on CL, CSX, NSC and WMT

On Monday, the 10-year Treasury yield spiked to 2.644 percent, the highest in nearly two years. The treasury yield has surged over 1 percent from its intraday low of 1.614 percent on May 1st. There are currently 165 companies (roughly 33 percent) in the S&P 500 Index with dividend yields higher than the 10-year Treasury yield, compared to 257 companies at the end of March. The recent surge in yields has triggered a selloff in dividend paying stocks among investors who flocked to the riskier equities in a low interest-rate environment.

Colgate-Palmolive Company (NYSE:CL - News) shares traded in the range of $56.42 to $57.20 Wednesday before settling to close at $57.00, an increase of 1.39 percent. The stock appears to be facing resistance at the $58.10 and $59.09 levels. The company currently pays a quarterly dividend of $0.34 a share, $1.36 annually, for a dividend yield of roughly 2.4 percent. Shares of Colgate-Palmolive have fallen approximately 6.8 percent in the past month.

More information on Colgate-Palmolive and access to the free equity report can be found at:
www.WallStreetFundamentals.com/CL

CSX Corporation (NYSE:CSX - News) shares traded in the range of $22.98 to $23.56 Wednesday before settling to close at $23.23, an increase of 0.39 percent. The stock appears to be facing resistance at the $23.39 and $23.71 levels. The company currently pays a quarterly dividend of $0.15 a share, $0.60 annually, for a dividend yield of roughly 2.6 percent. Shares of CSX have fallen approximately 9.0 percent in the past month.

More information on CSX and access to the free equity report can be found at:
www.WallStreetFundamentals.com/CSX

Norfolk Southern Corp. (NYSE:NSC - News) shares traded in the range of $72.70 to $74.24 Wednesday before settling to close at $73.35 an increase of 1.17 percent. The stock appears to be facing resistance at the $73.71 and $74.47 levels. The company currently pays a quarterly dividend of $0.50 a share, $2.0 annually, for a dividend yield of roughly 2.7 percent. Shares of Norfolk Southern have fallen approximately 5.5 percent in the past month.

More information on Norfolk Southern and access to the free equity report can be found at:
www.WallStreetFundamentals.com/NSC

Wal-Mart Stores, Inc. (NYSE:WMT - News) shares traded in the range of $74.54 to $75.18 Wednesday before settling to close at $75.01. The stock appears to be facing resistance at the $75.24 and $76.40 levels. The company currently pays a quarterly dividend of $0.47 a share, $1.88 annually, for a dividend yield of roughly 2.5 percent. Shares of Wal-Mart Stores have fallen approximately 3.0 percent in the past month.

More information on Wal-Mart Stores and access to the free equity report can be found at:
www.WallStreetFundamentals.com/WMT

Wall Street Fundamentals offers our members a full range of investor services including in-depth equity reports on your favorite companies and timely market updates featuring the hottest stocks trending in the marketplace.

Activate your always free membership by signing up at www.WallStreetFundamentals.com today.

Disclaimer: Information, opinions and analysis contained herein are based on sources believed to be reliable, but no representation, expressed or implied, is made as to its accuracy, completeness or correctness. The opinions contained herein reflect our current judgment and are subject to change without notice. We accept no liability for any losses arising from an investor's reliance on or use of this report. This report is for information purposes only, and is neither a solicitation to buy nor an offer to sell securities. Certain information included herein is forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements concerning manufacturing, marketing, growth, and expansion. Such forward-looking information involves important risks and uncertainties that could affect actual results and cause them to differ materially from expectations expressed herein. Wall Street Fundamentals has no financial relationship with any company whose stock is mentioned in this release.

Contact:
Wall Street Fundamentals
Website: www.WallStreetFundamentals.com
Email: editor@wallstreetfundamentals.com

Source: http://news.yahoo.com/wall-street-fundamentals-releases-depth-stock-reports-cl-123000508.html

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বৃহস্পতিবার, ২৭ জুন, ২০১৩

Report: Google Is Developing A Game Console - News - www ...

The Wall Street Journal is reporting that the tech giant Google is creating an Android-powered game console, and a wristwatch device that will connect with your Android phone.

According to the Wall Street Journal's Amir Efrati, his sources have revealed that Google "The Internet giant hopes to design and market the devices itself and release at least one of them this fall."

The report states that Google has been influenced to make the move partially in anticipation of Apple adding a considerable gaming element to the next generation of its Apple TV device, as well as the excitement over the Android-powered, Kickstarter-funded Ouya console which recently released.

The wristwatch product would likely connect with your phone via Bluetooth signal, and display information and interact with an Android phone.

The company is also planning on releasing a new version of its Android operating system this fall.

[Source: Wall Street Journal]

Source: http://www.gameinformer.com/b/news/archive/2013/06/27/report-google-is-developing-a-game-console.aspx

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Low self-control promotes selfless behavior in close relationships

June 27, 2013 ? When faced with the choice of sacrificing time and energy for a loved one or taking the self-centered route, people's first impulse is to think of others, according to new research published in Psychological Science, a journal of the Association for Psychological Science.

"For decades psychologists have assumed that the first impulse is selfish and that it takes self-control to behave in a pro-social manner," says lead researcher Francesca Righetti of VU University Amsterdam in the Netherlands. "We did not believe that this was true in every context, and especially not in close relationships."

Righetti and colleagues sought to examine whether impulsivity, in close relationships, might actually benefit others.

They found that participants whose self-control was taxed (and were thus more impulsive) were more willing to sacrifice time and energy for their romantic partner or best friend than participants whose self-control wasn't taxed.

In one study, to find out whether they would sacrifice in actual practice, the researchers told couples they would have to talk to 12 strangers and ask them embarrassing questions. The participants didn't know that they wouldn't actually have to follow through with the task.

Participants with high self-control opted to split the burden right down the middle -- assigning six strangers to themselves and six strangers to their partner. But participants with low self-control opted to take on more of the burden, sacrificing their own comfort to spare their partners.

A final experiment revealed that married individuals low in trait self-control sacrificed more for their partners, yet were also less forgiving of their transgressions -- presumably because self-control is required to override the focus on the wrongdoing and think instead about the relationship as a whole.

While sacrificing for a partner may help to build the relationship on a day-to-day basis, Righetti and colleagues note that it could backfire over the long-term, compromising individuals' ability to maintain a balance between personal and relationship-related concerns.

This balance is a perennial issue for anyone in a close relationship:

"Whether it's about which activities to engage in during free time, whose friends to go out with, or which city to live in, relationship partners often face a divergence of interests -- what is most preferred by one partner is not preferred by the other," notes Righetti.

The field of research is relatively new, so the jury is still out on what effects sacrifice has on relationship well-being, but Righetti is hopeful that research over the next few years will shed more light on the link.

Co-authors on this research include Catrin Finkenauer, also of VU University Amsterdam in the Netherlands, and Eli Finkel of Northwestern University.

This research was supported by grants from the Netherlands Organization for Scientific Research.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/vEB9BGp7PWA/130627142553.htm

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Lemurs' group size predicts social intelligence

Primates that live with many others know not to steal food when someone is watching

Primates that live with many others know not to steal food when someone is watching

By Cristy Gelling

Web edition: June 26, 2013

Enlarge

A ring-tailed lemur chooses food on a plate next to a person with his back turned, rather than trying to take it from someone watching.

Credit: E.L. MacLean et al/PLOS ONE

View the video

Never turn your back on a lemur ? especially if it?s a member of a big gang.

Lemur species that live in large groups can tell when to steal food from a competitor in a lab experiment, researchers report June 26 in PLOS ONE. The finding supports the idea that brain power in primates evolved to fit their complex social lives. Because the sneakier lemurs have the same size brains as less-sneaky ones living in smaller groups, researchers suggest that social smarts don?t always depend on brain size.

Much of the evidence for sociality?s role in the evolution of intelligence comes from indirect measures such as brain size, says study coauthor Evan MacLean of Duke University. But brain size does not always correspond to brain power, so MacLean uses behavioral tests.

He and his colleagues tested the social intelligence of six species of lemurs, primates from Madagascar distantly related to monkeys and apes. Each of the species lives in social groups ranging from families of just three, mongoose lemurs? preferred posse, to gangs of about 16, a typical size for a group of ring-tailed lemurs.

The researchers trained lemurs to view humans as competitors for food, then presented the animals with a choice between pilfering treats from one of two people: one facing the animals or another with his or her back turned. Species that live in small groups reached for the food under a competitor?s nose as often as they did behind people?s backs. But the ring-tailed lemurs were much more likely to choose the unguarded food.

Most intriguing, says Susanne Shultz, a biological anthropologist at England?s University of Manchester, is that group size was much better than brain size at predicting which species would perform well in either the social intelligence test or in a separate nonsocial intelligence test. ?We assume that if you have a bigger brain you should be better at solving problems,? she says. Her own research suggests that brain size in primates does correspond to cognitive ability, but she used a different set of intelligence tests and more kinds of primates. She says she would be interested to see how other species perform on MacLean?s tests.

MacLean agrees that a general relationship probably exists between brain size and cognition. But he speculates that this might not be the case with very closely related species like the lemurs. ?Cognition might evolve a little bit ahead of brain size,? he says.

In pre-trial training, a ring-tailed lemur learns that a person watching is a competitor for a morsel of food. The animal then chooses to take food from behind a person?s back, rather than from a watchful person.
Credit: E.L. MacLean et al./PLOS ONE, 2013.

Source: http://www.sciencenews.org/view/generic/id/351237/title/Lemurs_group_size_predicts_social_intelligence

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The Other Mexicans

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The Other Mexicans
The number of Mexicans of indigenous origin in the U.S. is growing fast, but they are largely overlooked in the debate on immigration reform.

Source: National Geographic News
Posted on: Tuesday, Jun 25, 2013, 8:07am
Views: 11

Source: http://www.labspaces.net/128772/The_Other_Mexicans_

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'Dangerous' innovation in legal highs leaves governments in the ...

By Stephen C. Webster
Wednesday, June 26, 2013 13:18 EDT

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An explosion of hundreds of new ?legal highs? in recent years has left governments around the world in the dust as lawmakers struggle to keep prohibition laws updated as more and more never-before-seen drugs flood the black market.

The United Nations Office on Drugs and Crime (UNODC) said Wednesday that more than 251 new psychoactive substances were available on the black market by mid-2012, a growth of more than 50 percent over 2009. The UNODC?s 2013 World Drug Report finds that these substances are ?proliferating at an unprecedented rate and posing unforeseen public health consequences.?

The situation has become so severe that the study says the number of new psychoactive substances available on the black market today exceeds the number of controlled psychoactive substances currently prohibited by governments around the world.

One of the problems governments are having with these rapidly emerging substances is that when they place one drug on a schedule of controlled substances, chemists slightly tweak the molecular structure and re-release the drug, once again technically legal thanks to tiny changes.

?There is a lack of long-term data which would provide a much-needed perspective: no sooner is one substance scheduled, than another one replaces it, thus making it difficult to study the long-term impact of a substance on usage and its health effects,? the study notes.

In other words, prohibition laws have now created a game of cat-and-mouse between authorities and the developers of untested new drugs, and the drug developers are winning. A similar effect was observed in the U.S. after authorities banned the psychoactive chemicals in the marijuana-substitute ?Spice,? leading to hundreds of variants of the synthetic drug, some with terrifying physical and psychological side-effects.

The UNODC study said that the global body is now coordinating a rapid-response system that will warn governments of these new drugs as they are discovered on streets around the world.

?We have agreed on a path for our ongoing discussion,? UNODC?s executive director, Yury Fedotov, said in an advisory. ?I hope it will lead to an affirmation of the importance of the international drug control conventions, as well as an acknowledgement that the conventions are humane, human-rights centered and flexible. There must also be a firm emphasis on health and we must support and promote alternative sustainable livelihoods. It is also essential that we recognize the important role played by criminal justice systems in countering the world drug problem and the need for enhanced work against precursor chemicals.?
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[Photo: Flickr user Angelo Gonzales, creative commons licensed.]

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Source: http://www.rawstory.com/rs/2013/06/26/explosion-of-dangerous-legal-highs-leaves-prohibition-in-the-dust/

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Brazil's Rousseff calls for constitutional vote to quell protests

By Brad Haynes and Maria Carolina Marcello

SAO PAULO/BRASILIA (Reuters) - Brazilian President Dilma Rousseff sought to overcome a sudden wave of national discontent with a surprising call on Monday for a referendum on what would be the country's most ambitious political reform in decades.

Rouseff proposed a national vote on amending Brazil's constitution in a meeting with governors and mayors the week after the country's largest protests in 20 years jolted politicians of all stripes. It immediately raised questions about whether she could deliver on such an undertaking as she heads to what may be a more difficult re-election in 2014.

Brazil's last sweeping political reform was 25 years ago, when the current Brazilian constitution was ratified in 1988 by the country's last constitutional assembly, three years after the end of its military dictatorship.

"The streets are telling us that the country wants quality public services, more effective measures to combat corruption ... and responsive political representation," Rousseff said, reiterating her support for the democratic spirit of most protesters gathering in Brazil's biggest cities in recent weeks.

It was unclear how Rousseff sought to address political reform, and analysts said her proposal may only add to concerns about whether she can placate protesters whose demands vary but ultimately come down to disillusionment with government.

A constitutional reform could take years as the government must arrange a public vote calling an assembly to debate the overhaul of Brazil's representative democracy.

"The creation of a Constituent Assembly to deliver a deep cutting political reform could add another element of medium-term uncertainty," wrote Alberto Ramos, chief Latin American economist at Goldman Sachs, in a note to clients.

"These transformational events tend to take a long time and the final outcome is extremely hard to predict," he added.

The president also laid out proposals to expand public transport, improve health services and crack down on corruption - concerns raised by the leaderless protest movement that has shaken markets and threatened her popularity.

Still, a sluggish economy has left the president with little room to maneuver the federal budget and protesters are unlikely to see rapid improvements in their daily lives.

Polls taken before the current wave of demonstrations showed public approval for the left-leaning Rousseff had slipped to around 55 percent - enough to win a second term in a single round of voting. She is widely expected to seek re-election next year.

The recent peak of the mostly peaceful demonstrations came on Thursday, when about a million people took to the streets across Brazil with occasional flashes of violence and vandalism.

The days since then have been calmer but social media points to another round of protests surrounding a Wednesday soccer match between Brazil and Uruguay in the city of Belo Horizonte.

Soccer has become a focal point for protesters objecting to big funding for stadiums for the 2014 World Cup that they believe would be better spent on transport, education and hospitals.

The demands for better public services have raised concerns about looser government spending, which Rousseff sought to head off by introducing her agenda on Monday with a call for fiscal discipline.

Rousseff then proposed an additional 50 billion reais ($22 billion) of investments to address the complaints about public transport that first set off the protests over two weeks ago.

Fare hikes for buses and subways in Sao Paulo and Rio de Janeiro that incited early outrage have since been withdrawn, and the governor of Sao Paulo also announced on Monday plans to roll back higher tolls on the state's highway concessions.

Rousseff also cited demonstrators' demands to lend urgency to parts of her agenda that have faced political resistance, such as setting aside future oil royalties for education and importing doctors from abroad.

She may struggle to find new tax revenue for her proposals, however, as the economy struggles to gain steam, inflation is eating away at purchasing power, and rising interest rates are making consumer credit more costly.

Two years of what many economists decry as fiscal slippage under Rousseff have also made it tougher to increase spending.

Standard & Poor's revised its outlook on long-term ratings for Brazil's sovereign debt this month to negative from stable, citing a deteriorating fiscal outlook and slow economic growth.

($1 = 2.25 Brazilian reais)

(Additional reporting by Caroline Stauffer and Eduardo Simoes in Sao Paulo and Maria Pia Palermo in Rio de Janeiro; Editing by Cynthia Osterman, Mary Milliken and Lisa Shumaker)

Source: http://news.yahoo.com/brazils-rousseff-calls-constitutional-vote-quell-protests-021543804.html

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Swiss court blocks Credit Suisse data transfer to U.S

GENEVA (Reuters) - A Swiss court has ordered an injunction halting the transfer of a former Credit Suisse employee's data to U.S. authorities as part of the bank's attempt to settle a tax investigation, a lawyer involved in the case said on Tuesday.

Douglas Hornung, a Geneva-based lawyer acting for the former Credit Suisse employee, said the ruling was made on June 21, confirming a preliminary decision in January.

The judgment could render it more difficult for banks to reach individual settlements with U.S. authorities in a long-standing row over tax evasion.

Credit Suisse spokesman Marc Dosch declined to comment.

The court ruling comes only days after Swiss lawmakers threw out a draft law aimed at providing a legal basis for banks to hand over this kind of data to U.S. authorities in an attempt to avoid prosecution.

The government plans an executive order to allow banks to hand over data but its efforts could be stymied by more legal action by bank staff fearful of U.S. extradition if they leave the country.

"It will set a precedent and could be repeated for other employees who had access to U.S. clients," Hornung, who also represents other former bankers, told Reuters on Tuesday.

Credit Suisse, like other Swiss banks subject to U.S. investigations, has already made several transfers of data on employees linked to accounts of its U.S. customers in an attempt to avoid indictment and minimize fines.

The last transfer was in June.

Switzerland's biggest bank, UBS, was forced to pay a $780 million fine in 2009 and deliver the names of more than 4,000 clients to avoid indictment.

However, a U.S. indictment felled Wegelin & Co this year. Switzerland's oldest private bank paid a $58 million fine and closed its doors for good after pleading guilty to helping Americans to evade taxes through secret accounts.

(Reporting by Emma Farge and Katharina Bart; Editing by David Goodman)

Source: http://news.yahoo.com/swiss-court-blocks-credit-suisse-data-transfer-u-124541285.html

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Toy Industry Hall of Fame to locate at Toy HOF

ROCHESTER, N.Y. (AP) ? The great minds of the toy industry will be honored alongside the famous toys they created under a new partnership being announced at the Strong Museum in Rochester.

Museum officials say the National Toy Hall of Fame housed at the museum is being combined with the Toy Industry Hall of Fame, which honors individuals. Past inductees include Milton Bradley, Frederick August Otto Schwarz and George Lucas.

Officials say the groups have been talking for some time about combining their respective halls as a way to raise their visibility and exposure and to promote their educational missions.

The new expanded hall is expected to open at the Strong Museum in the fall of 2015 after undergoing $4 million in renovations.

Source: http://news.yahoo.com/toy-industry-hall-fame-locate-toy-hof-151459161.html

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Live coverage of George Zimmerman murder trial

After spending a few days roasting over an open fire, Paula Deen is cooked. She lost her job with the Food Network on Friday meaning that she is, for all intents and purposes, gone from our lives now. But an unusual voice spoke up in her defense last night: professional opinioner Bill Maher. Eater pointed us towards this video of Maher defending the former Food Network star on last night's?Real Time with Bill Maher. ...

Source: http://news.yahoo.com/george-zimmerman-murder-trial--live-video-and-chat-222843188.html

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Israeli aircraft strike targets in Gaza Strip

JERUSALEM (AP) ? Israeli aircraft pounded targets in the Gaza Strip early Monday after rockets were fired at Israel from the territory, the military said, unsettling a tenuous cease-fire between Israel and Hamas.

The military said its aircraft struck two weapons storage facilities and a rocket launch site. No injuries were reported.

Rocket fire from Gaza has declined since Israel carried out an eight-day military campaign last November in response to frequent attacks. An Egyptian-brokered cease-fire has largely held, but sporadic fire still persists.

No militant group claimed responsibility for the rocket launch, but Israel said it holds Hamas, which rules the coastal territory, accountable.

"Last night's rocket attack is an intolerable act of aggression against Israel and its civilians. Hamas is held accountable for all acts of terrorism deriving from the Gaza Strip," said military spokesman Lt. Col. Peter Lerner.

Israeli police spokesman Micky Rosenfeld said a total of six rockets were fired at Israel overnight, causing no damage or injuries. The military said two rockets were intercepted by the "Iron Dome" missile defense system. The other four landed in open areas.

Israeli Prime Minister Benjamin Netanyahu responded to the rocket fire, saying "my policy is to harm whoever tries to harm us ... That is how we will work and will continue to act against threats that are close and threats that are far."

In Gaza, Hamas Prime Minister Ismail Haniyeh said he would not be intimidated by Israel's strikes. "Any Israeli aggression does not scare the Palestinian people," he said.

Israel last struck in Gaza in April, when its aircraft hit and killed a top militant in a shadowy al-Qaida-influenced group who had been involved in a rocket attack. The rocket was launched from Egypt's Sinai Peninsula, where Gaza militants are believed to operate. A rocket last landed in Israel in May.

Meanwhile, Israeli police said that vandals slashed the tires of 21 cars in an Arab neighborhood of east Jerusalem. The vandals also scribbled slogans on nearby walls.

It was the latest in a wave of crimes linked to Jewish extremists that has targeted mosques, churches, monasteries, dovish Israeli groups and even Israeli military bases to protest what they perceive as the Israeli government's pro-Palestinian policies in the West Bank. Vandals call the attacks the "price tag" for the policies they oppose. Last week vandals struck an Arab village outside of Jerusalem that has been a model of coexistence in Israel.

Rosenfeld said police were investigating. He said no arrests have been made in the recent string of similar crimes.

___

Associated Press writer Ibrahim Barzak contributed reporting from Gaza City, Gaza Strip.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-06-24-Israel-Palestinians/id-2cfc053cc5ea4350bba049f0eb13a155

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Analysis - Al Qaeda's Syria rift may lead to open conflict among jihadis

By Mariam Karouny

BEIRUT (Reuters) - A rift between Syrian jihadis and their fellow fighters from al Qaeda's Iraqi wing may lead to internecine war among some of the most effective rebel groups in combating President Bashar al-Assad.

Trouble has been brewing since April over what Syria's Nusra Front regards as a power grab by Abu Bakr al-Baghdadi, leader of the Islamic State of Iraq. Now, Baghdadi's insistence that he will keep fighting as head of a united jihadi brigade in Syria, defying orders from al Qaeda chief Ayman Zawahri, has brought the two groups close to turning on each other.

"Tension is increasing, it is about to reach boiling point. Both sides are saying they are right. A clash between them could occur soon and if it happens, it will be ugly," said a senior rebel commander in Damascus who is following the dispute.

The two-year uprising against Assad has drawn fighters from many foreign countries to both sides, in what is increasingly a sectarian struggle between the main denominations of Islam. Some Iraqi Shi'ites are fighting for Assad, whose Alawite sect is an offshoot of Shia Islam, while Iraqi Sunni radicals who once took on U.S.-led forces at home have joined the Syrian rebels.

Baghdadi's attempt to unite the Syrian and Iraqi wings of al Qaeda has provoked the dispute at a sensitive time when some Western governments are considering arming more moderate rebels, but fear the weapons might fall into the radicals' hands.

In April Baghdadi announced his Islamic State of Iraq was merging with the Nusra Front, which has staged some of the deadliest attacks on Assad's forces.

This apparently unilateral move opened up bitter and public rifts with the Nusra Front leadership - which resisted what it saw as his bid for overall power - and with Zawahri, the global al Qaeda leader who instructed him to put the merger on hold in an apparent attempt to settle the row.

Baghdadi dismissed the demand from Zawahri, who has headed al Qaeda since U.S. forces killed Osama bin Laden in 2011. The merged Islamic state of Iraq and Levant "is staying as long as we have a pulse and an eye that blinks... We will not compromise over its existence," Baghdadi responded earlier this month.

"After consultation I decided to (follow) the order from God over the order that opposes it," he added in an audio message.

Nusra fighters, other rebels and Islamic sources reacted by saying Baghdadi had effectively severed his al Qaeda links.

"He rejected the ruling of Sheikh Zawahri and therefore he is no longer a brother of al Qaeda," said a senior Nusra commander. "After Sheikh Zawahri ruled in our favor, the State (Islamic State of Iraq and Levant) is illegitimate."

PUSHING BAGHDADI OUT

A source close to Nusra leader Abu Mohammad Golani described Baghdadi's defiance as dangerous. "We have no choice but to confront them, or Zawahri himself has to deal with these people," he said.

Nusra was ready to fight Baghdadi's forces and kick them out of Syria, but "Golani does not want bloodshed among brothers in Islam, he added. "Right now there is a decision to avoid them... but if he acts in a way that goes against Syria's interest he will be pushed out by force, him and his people."

Beneath the bluster, Nusra fighters appear to be in no position for now to challenge Baghdadi's forces, and would need time to regroup and find allies among Syria's other rebels.

A senior commander from a hardline Islamist rebel brigade in the northern province of Idlib said Baghdadi's men would probably win a direct clash.

"Nusra was weakened by (Baghdadi's) takeover and weakened even more by the split that happened," he said. "It will be very difficult for Golani or anybody to bring it back from ashes."

With powerful, mostly foreign, fighters on his side, Baghdadi forced Golani and some of his men to go underground, confiscating some Nusra weapons. Many other Nusra fighters went home or joined other Islamist brigades.

But the source close to Golani said the fact that most of Baghdadi's fighters were non-Syrians meant they could end up isolated, even among the jihadis, because they were more concerned with imposing an Islamist agenda than toppling Assad.

Resentment about Baghdadi's agenda in Syria echoes the way that al Qaeda fighters alienated many Sunni fighters during the Iraqi insurgency against the U.S. occupation forces and the Shi'ite-led government in Baghdad. This could encourage other rebel brigades to join a Nusra backlash against Baghdadi.

"Baghdadi and those who believe in his extreme thinking, they are mostly foreigners and they are on their own," the source said. "Nusra is back to work," he added, saying Golani had ordered his commanders to prepare to resume operations.

Despite losing ground to Baghdadi's men in the north, particularly in Aleppo and Raqqa provinces, rebels say the Nusra Front remains active and prominent in operations in the southern province of Deraa, near the border with Jordan.

Any resurgence of the Nusra Front, which fights alongside other rebel brigades against Syrian government forces, would further complicate Western efforts to support Assad's opponents.

The United States has been reluctant to arm the rebels because of fears that weapons could end up in the hands of anti-Western jihadis such as the Nusra fighters. However, after a string of Assad gains around Damascus and near the Lebanese border, backed by Lebanon's Shi'ite militia Hezbollah, President Barack Obama said Washington would increase military aid.

ARMING A FRACTURED FORCE

Any weapons which are sent would flow into a fractured rebel force. "Nusra believe, and they are right, that this is their land, it is their Syria and they have the right to lead the battle here," said the senior rebel commander in Damascus.

Islamist sources close to al Qaeda's thinking say that Baghdadi's attempt to merge the Iraq and Syrian wings of the movement did not contradict Zawahri's belief in a hierarchy and structure that could form the basis of a powerful Islamic state.

Unlike bin Laden, who believed al Qaeda should train fighters to carry out attacks across the globe, possibly autonomously, Zawahri wanted a more rigid command structure.

Baghdadi's failure to consult over the merger and Golani's popularity among Islamist rebels, in contrast to the way al Qaeda alienated itself in Iraq, made it unacceptable.

"Golani is the son of Syria and he was so far doing a great job in paving the way for the creation of the (Islamic) state as a choice of people not by force, so Baghdadi in a way is an obstacle," the source said.

(Editing by Dominic Evans and David Stamp)

Source: http://news.yahoo.com/analysis-al-qaedas-syria-rift-may-lead-open-150027715.html

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The genome's 3-D structure shapes how genes are expressed

The genome's 3-D structure shapes how genes are expressed [ Back to EurekAlert! ] Public release date: 23-Jun-2013
[ | E-mail | Share Share ]

Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research

Scientists from Australia and the United States bring new insights to our understanding of the three-dimensional structure of the genome, one of the biggest challenges currently facing the fields of genomics and genetics. Their findings are published in Nature Genetics, online today.

Roughly 3 metres of DNA is tightly folded into the nucleus of every cell in our body. This folding allows some genes to be 'expressed', or activated, while excluding others.

Dr Tim Mercer and Professor John Mattick from Sydney's Garvan Institute of Medical Research and Professor John Stamatoyannopoulos from Seattle's University of Washington analysed the genome's 3D structure, at high resolution.

Genes are made up of 'exons' and 'introns' the former being the sequences that code for protein and are expressed, and the latter being stretches of noncoding DNA in-between. As the genes are copied, or 'transcribed', from DNA into RNA, the intron sequences are cut or 'spliced' out and the remaining exons are strung together to form a sequence that encodes a protein. Depending on which exons are strung together, the same gene can generate different proteins.

Using vast amounts of data from the ENCODE project*, Dr Tim Mercer and colleagues have inferred the folding of the genome, finding that even within a gene, selected exons are easily exposed.

"Imagine a long and immensely convoluted grape vine, its twisted branches presenting some grapes to be plucked easily, while concealing others beyond reach," said Dr Mercer. "At the same time, imagine a lazy fruit picker only picking the grapes within easy reach.

"The same principle applies in the genome. Specific genes and even specific exons, are placed within easy reach by folding."

"Over the last few years, we've been starting to appreciate just how the folding of the genome helps determine how it's expressed and regulated,"

"This study provides the first indication that the three-dimensional structure of the genome can influence the splicing of genes."

"We can infer that the genome is folded in such a way that the promoter region the sequence that initiates transcription of a gene is located alongside exons, and they are all presented to transcription machinery."

"This supports a new way of looking at things, one that the genome is folded around transcription machinery, rather than the other way around. Those genes that come in contact with the transcription machinery get transcribed, while those parts which loop away are ignored."

###

*ENCODE project

The National Human Genome Research Institute launched a public research consortium named ENCODE, the Encyclopedia Of DNA Elements, in September 2003, to carry out a project to identify all functional elements in the human genome sequence.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


The genome's 3-D structure shapes how genes are expressed [ Back to EurekAlert! ] Public release date: 23-Jun-2013
[ | E-mail | Share Share ]

Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research

Scientists from Australia and the United States bring new insights to our understanding of the three-dimensional structure of the genome, one of the biggest challenges currently facing the fields of genomics and genetics. Their findings are published in Nature Genetics, online today.

Roughly 3 metres of DNA is tightly folded into the nucleus of every cell in our body. This folding allows some genes to be 'expressed', or activated, while excluding others.

Dr Tim Mercer and Professor John Mattick from Sydney's Garvan Institute of Medical Research and Professor John Stamatoyannopoulos from Seattle's University of Washington analysed the genome's 3D structure, at high resolution.

Genes are made up of 'exons' and 'introns' the former being the sequences that code for protein and are expressed, and the latter being stretches of noncoding DNA in-between. As the genes are copied, or 'transcribed', from DNA into RNA, the intron sequences are cut or 'spliced' out and the remaining exons are strung together to form a sequence that encodes a protein. Depending on which exons are strung together, the same gene can generate different proteins.

Using vast amounts of data from the ENCODE project*, Dr Tim Mercer and colleagues have inferred the folding of the genome, finding that even within a gene, selected exons are easily exposed.

"Imagine a long and immensely convoluted grape vine, its twisted branches presenting some grapes to be plucked easily, while concealing others beyond reach," said Dr Mercer. "At the same time, imagine a lazy fruit picker only picking the grapes within easy reach.

"The same principle applies in the genome. Specific genes and even specific exons, are placed within easy reach by folding."

"Over the last few years, we've been starting to appreciate just how the folding of the genome helps determine how it's expressed and regulated,"

"This study provides the first indication that the three-dimensional structure of the genome can influence the splicing of genes."

"We can infer that the genome is folded in such a way that the promoter region the sequence that initiates transcription of a gene is located alongside exons, and they are all presented to transcription machinery."

"This supports a new way of looking at things, one that the genome is folded around transcription machinery, rather than the other way around. Those genes that come in contact with the transcription machinery get transcribed, while those parts which loop away are ignored."

###

*ENCODE project

The National Human Genome Research Institute launched a public research consortium named ENCODE, the Encyclopedia Of DNA Elements, in September 2003, to carry out a project to identify all functional elements in the human genome sequence.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-06/giom-tg3062013.php

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Dear Lillie: Final Tour of our Townhome


Well, seeing how we spent the weekend moving out of our townhouse and tomorrow morning (Monday) will be moving into our new home I thought it would be a fitting time to give a final tour of our old home. When you first walked through our front door we had this tiny little space that kind of functioned as our entry area.

Directly next to the bench was our staicase. You can see the before here and how we very inexpensively made the frames here.


I am going to share a lot more living room photos this week as part of the One Room, Three Ways Series so for today will just share one and will come back and update it and add more once I post them. But this is how it last looked:

And here were the last photos I took of the dining room (although I ended up putting the chairs back in the family room):

And the ever-changing dining room chalkboard:



The dining room lead into the kitchen:



And the kitchen opens up to the family room:




And off the kitchen/family room is the back porch:



?When you head upstairs the first bedroom was Lillie's (and recently it became Lola's too once she moved into a "big girl bed").


And then there's Lola's room:


And lastly our room:



Well, that's it! We have made so many memories in this home and it is the only place Lillie and Lola have ever lived so it was sad to say good-bye to it but we are so excited about this next chapter in our lives!

***If you have any questions about where an item is from, paint colors or how something was made be sure to click here for our "Our Home" page that has all sorts of details,? here for our "Tutorials" page, or here for our "FAQ's" page. We don't have our internet hooked up yet at our new house so I will probably get pretty behind on responding to comments.

I'll be back Tuesday Morning with Day 1 of the my One Room, Three Ways!

Source: http://dearlillieblog.blogspot.com/2013/06/final-tour-of-our-townhome.html

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Southwest cancels 57 flights after computer glitch

CHICAGO (AP) ? Southwest Airlines expects some lingering delays Saturday morning after a system-wide computer failure caused it to ground 250 flights for nearly three hours late Friday night.

Full service was restored just after 2 a.m. EDT Saturday, but the Dallas-based airline is still working to clear a backlog of flights and reposition planes and crew.

The airline ? the country's largest domestic carrier ? canceled 43 flights Friday night and another 14 Saturday morning.

Southwest is the latest airline to ground flights because of a large computer outage. But its problem was minor compared to those experienced by two competitors ? thanks in part to its late-day timing.

In April, American Airlines grounded all of its flights nationwide for several hours due to computer problems. The airline ultimately canceled 970 flights. And last year, United Airlines had two major outages: one in August delayed 580 flights; another in November delayed 636 flights.

The problem was detected around 11 p.m. EDT Friday, Southwest spokesman Brad Hawkins said. It impaired the airline's ability to do such things as conduct check-ins, print boarding passes and monitor the weight of each aircraft. Some flights were on the taxiway and diverted back to the terminal, Hawkins said. Flights already in the air were unaffected.

Most of Southwest's cancelations Friday night were in the western half of the country, according to airline spokeswoman Michelle Agnew. Saturday's cancelations were scattered across the U.S. They included planes leavings from Minneapolis, Chicago, Phoenix, Denver and San Diego, according to flight tracking service FlightAware.

Southwest flies an average of 3,400 flights each day.

Agnew said in an email Saturday morning that the airline's technology team is "still working to confirm the source of the issue."

Shortly after 2 a.m., Southwest posted on its Twitter page that "systems are operating and we will begin work to get customers where they need to be. Thanks for your patience tonight."

Agnew said the computer system was "running at full capacity" by early Saturday. Before that, though, officials used a backup system that was much more sluggish.

______

AP Airlines Writer Scott Mayerowitz in New York contributed to this report.

Source: http://news.yahoo.com/southwest-cancels-57-flights-computer-glitch-104716565.html

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